Federation of American Scientists Case Studies in Dual Use Biological Research Module 5.0: Antibiotic Resistance Case Study
Topic: References

References for Experiments in Antibiotic Resistance
Hemann MT, Fridman JS, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C, Hannon GJ, Lowe SW, “An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo,” Nature Genetics, 33:396-400 (2003).
References for Implications
Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradsahw J, Burchard J, Kulkarni A, Cavet G, Sachidanandam R, McCombie R, Cleary MA, Elledge SJ and Hannon GJ, “Second-generation shRNA libraries covering the mouse and human genomes,” Nature Genetics, 37:1281-1288 (2005).
Stegmeier F, Hu G, Rickels RJ, Hannon GJ, Elledge SJ, “A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells,” Proceedings of the National Academy of Sciences of the USA, 102:13212-13217 (2005).
Paddison PJ, Cleary M, Silva JM, Chang K, Sheth N, Sachidanandam R, Hannon GJ, “Cloning of short hairpin RNAs for gene knockdown in mammalian cells,” Nature Methods, 1:163-167 (2004).
OpenBiosystems product information, “Biosafety Features – the safest lentiviral system for expression,” accessed on 12/7/07, available at http://www.openbiosystems.com/Viral%20Packaging/TransLentiviral%20Packaging%20Syst/Biosafety/.
OpenBiosystems product information, “LinX retroviral expression system for RNA,” accessed on 12/7/07, available at http://www.openbiosystems.com/collateral/rnai/pi/LNX1500.pdf.
National Institutes of Health, “Biosafety in Biomedical and Microbiological Laboratories – Laboratory Biosafety Level 2 (BSL2),” accessed on 12/7/07, available at http://bmbl.od.nih.gov/sect3bsl2.htm.
References for Discussion
Cullen B, “RNAi the natural way,” Nature Genetics, 37:1163-1165 (2005).
Meltzer P, “Small RNAs with big impacts,” Nature, 35:745-746 (2005).

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