1998 Army Science and Technology Master PlanThe National Defense Act for FY94, Public Law 103160, consolidated management and funding of both medical and nonmedical chemical and biological defense (CBD) programs under OSD and in separate defense accounting lines. The law designated the Army as executive agent to coordinate and integrate the CBD acquisition program. In that capacity, the Army has elected to present the CBD program in this Science and Technology Master Plan. The nonmedical CBD programs are discussed here in Section IVE, while the medical CBD programs are addressed in Section IVQ, "Medical and Biomedical Science and Technology."
The CBD program includes those technological efforts that maximize a strong defensive posture in a biological or chemical environment, using passive and active means as deterrents to the use of weapons of mass destruction. These technologies include the areas of chemical and biological (CB) detection, information assessment (including identification, modeling, and intelligence), contamination avoidance, protection of individual soldiers and equipment, and collective protection against weapons of mass destruction.
Defense against CB agents is accomplished at several levels: enhancing survivability of land combat systems and helicopters, detecting CB agents before personnel are exposed, protecting personnel once agents are employed, decontaminating following exposures, and providing safe and effective medical countermeasures. Related areas include modeling and simulation (M&S) of agent characteristics and modernizing armored systems for CB survivability.
a. Detection
Goals and Timeframes
Standoff shortrange CB detection is being pursued with lasers that can detect, identify, and map chemical vapors, aerosols, and liquids on the ground at ranges of 35 kilometers (km). The longer range biological threat will be detected at ranges up to 50 km using eyesafe lasers with enhanced imaging capability that will employ polarization and multiple wavelength excitation to increase discrimination range against natural biological backgrounds (FY00).
Passive technologies such as surfaceexcited infrared thermoluminescence, being studied for their ability to detect CB agents on the battlefield, require development of atmospheric databases, spectroscopic detection algorithms, and optical telescope designs for airborne and space platforms (FY10). These approaches are being evaluated against the use of multiple point sensors, either distributed throughout the battlespace or mounted on mobile platforms (FY02).
Because of the unique characteristics of CB agents, their physicochemical properties must be carefully mapped to ensure detection, and a theoretical basis for detecting unknown but related agents must be developed. Infrared, visible, and ultraviolet (UV) spectroscopy, as well as mass, Raman, and laser desorption or electrospray particle trap mass spectrometry (MS), are being applied to this problem. Finally, aerosol science is providing the basis for the development of new optical methods for interrogating aerosol clouds from a distance for the purpose of detection.
Closer to the soldier is point detection. New fluorescent, acoustic, and optical biosensors are being designed for enhanced sensitivity and more flexible detection capability. Recent advances in the acceleration of the polymerase chain reaction (PCR) on a miniaturized scale now permit the exploitation of DNA probes for field detection of pathogens. A major thrust of a Joint Warfighting Science and Technology Plan (JWSTP) Defense Technology Objective (DTO), J.04 "Integrated Detection Advanced Technology Demonstration (ATD)," is the development of a rapid, automated field detection device based on the PCR. One key DTO element is the development of recombinant antibodies to serve as the recognition element of these new biosensors (FY98). Recombinant antibodies will ultimately be designed and quickly selected from genetic "super libraries" (FY99) to have specific detection capabilities, and novel starburst dendrimers are being studied for use on tailored reactive surfaces. Another major approach to point detection is MS, and miniature automated pyrolysisbased versions are being assessed for integration into existing CBD platforms (FY01). Of critical importance for biosensor and MS approaches is bioaerosol sampling, since characteristics (e.g., concentration of detectable units per unit volume of air) of biological aerosols differ dramatically from chemical vapors, with resulting effects on detection efficacy (see Figure IV1).

Figure IV-1. Bioaerosol Sampler and Detector
Major Technical Challenges
In the postWorld War II era, detection was a simple matter of knowing what agents potential adversaries possessed and designing analytical procedures to detect them. The proliferation of a broad spectrum of biological agents such as toxins, viruses, and bacteria, and the potential for genetically engineered pathogens have complicated this task immeasurably. The ideal detection system would operate continually in a standoff mode and would be capable of detecting all knownand even unknownagents.
Detection of biological weapons against a high and variable background of ambient biological material.b. Protection
Goals and Timeframes
The second major theme in CBD is protection, and this may be divided into individual and collective protection. The foci of individual protection are to reduce the physiological burden of the protective mask and clothing, thereby reducing performance degradation, to integrate the mask into future soldier systems, and to protect against future CB threat agents. To accomplish these goals, new materials will be needed to decrease breathing resistance (FY05) and increase binocular vision (FY05). Computeraided design (CAD) and rapid prototyping techniques are being employed to both improve mask performance and manufacturing processes. Supporting this, new physiological and protection tests are being developed. For clothing, selectively permeable and smart membranes are being assessed for enhanced protection and reduced heat stress. Selectively permeable membranes laminated to lightweight shell fabrics will provide low thermal insulation and high vapor transmission. Incorporation of reactive materials into the membrane will reduce the need for carbon and extend service life. Collective protection S&T efforts focus on advanced filtration and sheltering concepts for assembled troops that promise to reduce the power, weight, and volume of systems as well as to improve protection against NBC threats. Efforts to enhance vapor and aerosol filtration are concentrating on novel materials and processes. Temperature swing adsorption (TSA), pressure swing adsorption (PSA), and catalytic oxidation (CATOX), as well as improvements to existing singlepass filter systems, are under investigation to provide new systems requiring reduced logistical support through greatly increased service life and improved reliability against an evolving CB threat (FY01). Additionally, adsorbent materials with desirable surface characteristics and precisely controlled pore structures are under investigation to identify improvements to the traditional activated carbon substrates (FY10). Investigations are ongoing to assess regenerable fine particle filtration concepts with the potential of providing longterm protection against that class of NBC threats. Also under way are investigations of the integration of regenerative filtration technologies into host weapons systems, the ability to incorporate a surface acoustic wave sensor into a filter bed to signal impending loss of its filtration capacity, and performance of fielded filters against nonstandard threat materials such as industrial vapors. Finally, modeling efforts to describe filter performance based on fundamental properties and process parameters are in progress. Efforts to improve shelter technology are concentrating on novel materials that are more affordable and provide better protection against a broad range of NBC agents.
Major Technical Challenges
The major challenge will be to identify new materials offering improved protection against a broad and evolving spectrum of NBC agents while reducing the physiological burden to the soldier. More specifically:
Apply new adsorbent technology and materials to improve the performance of TSA and PSA processes as well as the traditional single pass filtration systems.c. Decontamination
Goals and Timeframes
The third major theme is decontamination, and this can be divided into three categories: immediatecarried out by the individual soldier, operationalcarried out by the decontamination unit, and thoroughperformed by the chemical company, usually at an equipment decontamination site. Both hydrolytic and oxidative reactions are being studied, with the goal of formulating stable decontaminants with new reactants for rapid destruction of mustard, and V and G nerve agents. Catalytic materials such as enzymes have been cloned and assessed for their ability to destroy chemical agents under mild, ambient conditions, thus avoiding damage to delicate equipment and the environment. An enzyme that degrades G class nerve agents has been scaled up and produced via biomanufacturing, and will be subjected to a NATO field test (FY98). Enzymes that degrade Vclass nerve agents are being screened for efficacy and downselected for scaleup (FY98). Ultimately, these new catalytic materials may be incorporated into sorbents and selfdecontaminating coatings, fibers, or paints (FY10) (see Figure IV2).

Figure IV-2. Molecular Model of Catalytic Oxidation
Major Technical Challenges
The main technical objective is to design decontaminating materials with highly catalytic properties, long shelf life, and an ability to function under a broad range of temperatures and pH.
Using molecular modeling and sitedirected mutagenesis, design catalytic enzymes with enhanced turnover (i.e., degradative) rates, and stability under various environmental conditions.d. Modeling and Simulation
Goals and Timeframes
The use of M&S is an essential aspect of the current and future CBD program. Advanced computer simulation technology will allow soldiers to be immersed in a realistic and physically accurate computergenerated combat environment that includes CB agent cloud movement and target effects under variable weather, terrain, and foliage conditions. This capability will allow the military user, for the first time, to experience the impact and consequences of CB weapons of mass destruction (WMD) in operational situations and, more important, will demonstrate the potential value of CBD equipment (FY01). Simulations of both conceptual and actual CBD equipment will result in improved and stable performance requirements to be established early in development (FY01). The distributed interactive simulation (DIS) network will enable the user to evaluate the "valueadded" of each CBD item at every phase of development (see Figure IV3). By means of virtual prototyping, soldiers will contribute to the detailed design of new equipment throughout the development cycle. The combination of constructive (wargaming) and virtual (3D) simulations will permit CBD hardware performance characteristics to be optimized prior to production. Virtual prototyping will greatly decrease the acquisition time and associated costs of development, including test and evaluation (T&E) elements. The mutual interaction between user and developer, provided by M&S throughout the acquisition cycle, will result in superior CBD products within the limited funding and resource constraints anticipated for the future.
Figure IV-3. Simulation of Intercept of Chenical or Biological Agent Munition
Click on the image to view enlarged version
As the threat evolves and proliferates, it becomes increasingly important to be able to identify, synthesize, and assess the physicochemical and toxicological properties of new compounds. These studies are being used to develop quantitative structureactivityproperty relationships and, ultimately, to predict the behavior of new compounds in biosystems. Novel, shortacting sedatives are being developed from these efforts as potential lessthanlethal chemicals for a variety of applications, and candidate nontoxic simulants with reduced environmental impact are also being selected and tested.
Major Technical Challenges
The two main objectives for M&S are to develop models that accurately predict the effect of chemical and biological warfare (CBW) agents on battlefield performance, as well as the protective capability of CBW defense equipment. Second, to model structureactivity relationships to predict the threat potential of new compounds and their behavior in both bio and ecosystems.
Develop a verifiable capability to analyze CB detectors and detection systems in existing "constructive" wargames.The roadmap of technology objectives for Chemical and Biological Defense is shown in Table IV10.
The influence of this technology area on TRADOC FOCs is summarized in Table IV11.
Table IV10. Technical Objectives for Chemical and Biological Defense |
|||
Technology Subarea |
Near Term FY9899 |
Mid Term FY0004 |
Far Term FY0513 |
| Detection | Genetically
engineered antibodies Flow cytometry as an immunoassay platform for biodetection |
Genetic super
library Early warning of bioagent detection at 15 km Automated single step point detection Subsymptomatic chemical agent interior monitor Early warning of aerosol cloud at 550 km Small, lightweight chemical monitor |
Lightweight CB
detection from unmanned ground vehicle (UGV)/unmanned aerial vehicle (UAV) platform Miniaturized photoarray detection/identification of biological agents Standoff chemical detection at 20 km CB water and surface contamination monitor Manportable integrated CB detection system |
| Individual Protection |
24hour
liquid protection 50% reduction in breathing resistance Develop advanced selectively permeable membrane eliminating/reducing the use of carbon in chemical protective ensembles |
50% increase in
binocular vision Expanded performance degradation model Compatibility with future soldier systems |
Full field of
view (FOV) through transparent face piece New super dense absorbents Smart barrier membranes |
| Collective Protection | Prototype
pressure swing absorption (PSA) system Laboratory scale temperature swing absorption (TSA) system |
Combined
PSA/TSA/CATOX system Engineered absorbents |
Monolithic
filtration media Membrane filtration |
| Decontamination | New polymers with agent reactive sites for more efficient decontamination (decon) | Automatic decon through conductive coatings | Selfdecon coatings |
| Modeling and Simulation |
Distributed interactive simulation capability for CB detectors | Upgraded wargames and virtual prototypes of CBD equipment | Virtual reality
using man in the loop Virtual/actual CBD equipment in fully integrated constructive and virtual combat simulations |
Table IV11. Chemical and Biological Defense Linkages to Future Operational Capabilities |
|
Technology Subarea |
Integrated and Branch/Functional Unique Future Operational Capabilities |
| Detection | TR 97020
Information Collection, Dissemination, and Analysis TR 97022 MobilityCombat Mounted TR 97030 Sustainment Maintenance TR 97043 SurvivabilityMateriel |
| Individual Protection | TR 97030
Sustainment Maintenance TR 97038 Casualty Care, Patient Treatment, and Area Support TR 97044 SurvivabilityPersonnel |
| Collective Protection | TR 97030
Sustainment Maintenance TR 97038 Casualty Care, Patient Treatment, and Area Support TR 97044 SurvivabilityPersonnel |
| Decontamination | TR 97030
Sustainment Maintenance TR 97038 Casualty Care, Patient Treatment, and Area Support |
| Modeling and Simulation | TR 97002
Situational Awareness TR 97052 Training Aids, Devices, Simulators, and Simulations Fidelity Requirements TR 97054 Virtual Reality TR 97057 Modeling and Simulation |